ビタミンKとγ-Gultamyl carboxylase遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンK-)

• 津川 尚子

  神戸薬科大学衛生化学研究室

書誌事項

タイトル別名

• Vitamin K and γ-Gultamyl Carboxylase Polymorphyisms
• ビタミンKとγ-Gultamyl carboxylase遺伝子多型
• ビタミン K ト g-Gultamyl carboxylase イデンシ タケイ

抄録

Vitamin K is a cofactor of γ-glutamyl carboxylase (GGCX) which is responsible for converting specific glutamyl residues to γ-carboxyglutamyl residues in a vitamin K-dependent protein (VKDP). Both of vitamin K and GGCX are essential for activation of VKDP, such as clotting factors II, VII, IX, and X, or osteocalcin which is a bone-related protein. Therefore, there is a possibility that the GGCX polymorphisms would affect activation of blood coagulation or bone formation. Specifically, the influence of rs699664 (Arg325Gln) single nucleotide polymorphism (SNP) in exon 8 and rs10654848 microsatellite in intron 6 on activation of clotting factors or bone metabolism have been reported frequently. Also, there are data that GGCX variants influence the dose requirement of warfarin in the general population. In this report, I would like to review about the kinds of GGCX polymorphism, and its effects on vitamin K action.

収録刊行物

• ビタミン

  ビタミン 87 (8), 435-439, 2013

  公益社団法人 日本ビタミン学会

キーワード

• Vitamin K
• γ-glutamyl carboxylase
• GGCX
• Coagulation
• Bone

詳細情報

• CRID: 1390282680646228864
• NII論文ID: 110009635557
• NII書誌ID: AN00207833
• DOI: 10.20632/vso.87.8_435
• ISSN: 2424080X
• ISSN: 0006386X
• NDL書誌ID: 024854648
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024854648
• Web Site: https://search.jamas.or.jp/link/ui/2014018090
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可