書誌事項
- タイトル別名
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- Polymorphisms of cytochromes P450 catalyzing vitamin D Hydroxylation
- ビタミンDとシトクロムP450の遺伝子多型
- ビタミン D ト シトクロム P450 ノ イデンシ タケイ
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抄録
CYP2R1 catalyzes conversion of vitamin D_3 to 25-hydroxyvitamin D_3 (25OHD3), while CYP27B1 catalyzes conversion of 25OHD_3 to 1α, 25-dihydroxyvitamin D_3 (1,25(OH)2D3), the active form of vitamin D_3 On the contrary, CYP24A1 inactivates 1,25(OH)2D3 by multi-step monooxygenation reactions. More than 30 CYP27B1 mutations containing missense and nonsense mutations have been found in vitaminD-dependent rickets type I (VDDR1) patients, while 3 types of CYP2R1 mutation were found in VDDR1 patients. Recently, more than 20 CYP24A1 mutations were found, and a clear relationship was revealed between CYP24A1 mutations and idiopathic infantile hypercalcemia. These findings clearly demonstrate that deficiency of one of the three CYPs could cause hypo- or hypervitaminnosis D, resulting in disruption of calcium homeostasis. Recently, several reports on CYP2R1 and/or CYP27B1 genes polymorphisms and susceptibility to type I diabetes were published. GG genotype of (G>A)(rs10741657) CYP2R1 polymorphism and CC genotype of -1260C>A (rs10877012) CYP27B1 polymorphism increased the risk of type I diabetes. In the immune system, 1,25(OH)2D3 has been shown to suppress Th1-type immune responses. Low levels of 25OHD3 and/or 1,25(OH)2D3 in GG type of CYP2R1 and CC type of CYP27B1 may explain the excessive Th1-type responses to result in an autoimmune disease, type I diabetes.
収録刊行物
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- ビタミン
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ビタミン 87 (9), 519-524, 2013
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680677282688
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- NII論文ID
- 110009636194
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 024898159
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可