精神疾患の中間表現型としての未成熟歯状回(2012年度 第2回フォーラム基礎心理学のための基礎研究-網膜,遺伝子,インタフェース-) Immature dentate gyms : A potential new endophenotype of psychiatric disorders(Forum : Basic research for psychonomics-Retina, genome, and Interface-)

この論文にアクセスする

この論文をさがす

著者

    • 昌子 浩孝 SHOJI Hirotaka
    • 藤田保健衛生大学総合医科学研究所システム医科学研究部門:科学技術振興機構戦略的創造研究推進事業(CREST) Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University:CREST, Japan Science and Technology Agency
    • 萩原 英雄 HAGIHARA Hideo
    • 藤田保健衛生大学総合医科学研究所システム医科学研究部門:科学技術振興機構戦略的創造研究推進事業(CREST) Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University:CREST, Japan Science and Technology Agency
    • 高雄 啓三 [他] TAKAO Keizo
    • 藤田保健衛生大学総合医科学研究所システム医科学研究部門:科学技術振興機構戦略的創造研究推進事業(CREST):生理学研究所行動・代謝分子解析センター行動様式解析室 Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University:CREST, Japan Science and Technology Agency:Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences
    • 宮川 剛 MIYAKAWA Tsuyoshi
    • 藤田保健衛生大学総合医科学研究所システム医科学研究部門:科学技術振興機構戦略的創造研究推進事業(CREST):生理学研究所行動・代謝分子解析センター行動様式解析室 Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University:CREST, Japan Science and Technology Agency:Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences

抄録

Maturation and integration of neurons and grial cells in the hippocampus is considered to be essential for regulating endocrine, affective, and congnitive functions, and the disruption of such process may cause mental illness. Previously, we have reported that mice heterozygous for a null mutation in α-CaMKII, which has a key role in a synaptic plasticity, show abnormal behaviors related to psychiatric disorders, such as schizophrenia and bipolar disorder. In these mutant mice, almost all neurons in the dentate gyrus are at a pseudo-immature properties, whihc we referred to as "immature dentate gyrus (iDG)." To date, the iDG phenotype have been found in mustant strains including Schnurri-2 knockout, SNAP-25 mutant, and forebrain-specific calcineurin knockout mice which show similar behavioral phenotypes. In addition, both chronic fluoxetine treatment and pilocarpine-induced seizures can reverse the maturation state of the mature neurons, resulting in the iDG phenotype in wild-type mice. Such iDG-like phenomenon was observed in the brains from patients with schizophrenia/bipolar disorder. Based on the findings, we proposed that the iDG is a potential new endophenotype of neuropsychiatric disorders. This review summarizes the behavioral abnormalities, iDG phenotype, and the implications in the pathophysiology of neuropsychiatric disorders.

収録刊行物

  • 基礎心理学研究

    基礎心理学研究 32(1), 101-119, 2013

    日本基礎心理学会

各種コード

  • NII論文ID(NAID)
    110009685451
  • NII書誌ID(NCID)
    AN00006194
  • 本文言語コード
    JPN
  • ISSN
    0287-7651
  • NDL 記事登録ID
    025090753
  • NDL 請求記号
    Z19-1361
  • データ提供元
    NDL  NII-ELS  J-STAGE 
ページトップへ