Bioinformatic characterization of sigma factors in Rothia mucilaginosa

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  • Rothia mucilaginosaゲノムにコードされるシグマ因子の生物情報学的解析
  • Rothia mucilaginosa ゲノム ニ コード サレル シグマ インシ ノ セイブツ ジョウホウガクテキ カイセキ

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Abstract

Our group recently determined the complete genome sequence of Rothia mucilaginosa strain DY-18, a clinical isolate from a persistent periapical periodontitis lesion. We bioinformatically determined that this strain possesses two sigma factors, one of which is a primary sigma factor that recognizes housekeeping promoters, and the other is an additional sigma factor whose promoter-binding activity may be regulated in response to physiolosical and environmental cues. Furthermore, the gene encoding the additional sigma factor is arranged in an operon-like structure with its cognate anti-sigma factor gene. Through multiple alignment analysis of the anti-sigma factor and its homologs, we found a conserved redox motif within these proteins. On the basis of these results, it was suggested that this sigma-antisigma regulatory system is a response to oxidative stress.

Journal

  • Shikaigaku

    Shikaigaku 73 (1), 12-18, 2010

    Osaka Odontological Society

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