P-22 Streptomyces属放線菌の生産する新規ポリケタイドalchivemycin類の構造(ポスター発表の部)
書誌事項
- タイトル別名
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- Structures of alchivemycins, novel polyketides from Streptomyces sp.
抄録
Actinomycetes have provided a diverse array of bioactive secondary metabolites. In particular, those belonging to the genus Streptomyces have been the most promising source of chemically diverse secondary metabolites. Their high capacity of secondary metabolite biosyntheis is largely attributable to the diversity of polyketide synthase (PKS) genes. In our continuing search for novel bioactive secondary metabolited from Streptomyces, we found a novel macrocyclic polyketide with an unprecedented framework from the culture extract of Streptomyces isolated from a leaf of chive Allium sp. For the production of the new compounds, the strain was fermented under a specific co-culturing condition with a bacterium Tsukamurella pulmonis. The 1-butanol extract of whole culture broth was separated by normal- and reversed-phase column chromatographies and HPLC to yield alchivemycins A (1) and B (2). Elucidation of the relative configurations of the alchivemycins was accomplished by a combination of NMR analysis and X-ray crystallography. Here we report the isolation and structure determination of the new compounds. This represents the first example of natural products containing a unique tetronic acid-tetramic acid hybrid substructure. Conpounds 1 and 2 inhibited tumor cell invasion without showing cytotoxic effects.
収録刊行物
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- 天然有機化合物討論会講演要旨集
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天然有機化合物討論会講演要旨集 51 (0), 533-538, 2009
天然有機化合物討論会実行委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681054633728
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- NII論文ID
- 110009757697
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- ISSN
- 24331856
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可