J022012 3-dimensional Optical Coherence Straingraphyを用いた動脈硬化プラークの脆弱性断層診断法の基礎的検討([J02201]診療技術と臨床バイオメカニクス(1))

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  • J022012 Fundamental Study on Vulnerability Diagnosis of Atherosclerosis using 3-Dimensional Optical Coherence Straingraphy

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Tissue vulnerability diagnosis of atherosclerotic plaques has been being required, because the rupture of unstable plaque on coronary artery should cause acute coronary syndromes. 3-Dimensional Optical Coherence Straingraphy (3D-OCSA) is proposed, which can visualize tissue mechanical information, e.g. strain distribution, from speckle deformation between synthetic 3-dementional images obtained by Optical Coherence Tomography. This is basically constructed by Recursive 3-dementional 1-41-(1' Cross-correlation as well as Image Deformation technique which take account of linear deformation of interrogation volume. Finally Weighted Moving Least Square Method can provide tomographic tissue strain distribution with high resolution. In this study, the experimental verification study was carried out using artificial phantoms of atherosclerotic plaque. 3D-OCSA detected tomographic distribution of residual strain in the phantom, which was compared with numerically simulated results. Consequently, both results were qualitatively analogous in terms of strain pattern. Then, 3D-OCSA was ex vivo applied to plaque lesions in WHHL rabbit aorta. Negative strain distributions identified the accumulation of lipid tissue having low elastic modulus. It was concluded that 3D-OCSA could be highly effective to clinical assessment of atherosclerosis as "Micro Mechanical Biopsy".

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  • 年次大会

    年次大会 2011 (0), _J022012-1-_J022012-5, 2011

    一般社団法人 日本機械学会

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