フローサイトメトリーによる血小板-白血球凝集と活性化血小板の解析

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  • Analysis of platelet-leukocyte aggregate and platelet activation using flow cytometry
  • フローサイトメトリー ニ ヨル ケッショウバン ハッケッキュウ ギョウシュウ ト カッセイカ ケッショウバン ノ カイセキ

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Thrombosis is one of the most important health problems among developed countries. Roles of Platelet-leukocyte interaction in thrombosis has been gradually recognized. Increase in platelet-leukocyte aggregate has been reported among patients with acute myocardial infarction and cerebral infarction. Increase in platelet-leukocyte aggregate has also been reported among patients with myeloproliferative neoplasms, for whom thrombosis is the major clinical problem. Platelet-leukocyte aggregate may be useful as a marker of thrombosis risk. We measured platelet-leukocyte aggregate and platelet activation among healthy volunteers using flow cytometry. Percentage of platelet-monocyte aggregate was higher than that of platelet-granulocyte aggregate, and showed larger individual variation. Percentage of activated platelet showed better correlation with percentage of platelet-monocyte aggregate than with platelet-granulocyte aggregate. Percentage of platelet-leukocyte aggregate changed widely during storage periods.

4

KJ00009144739

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