ビタミンKと骨代謝(<特集>第65回大会シンポジウム「臨床とビタミンUp-Date」)

• 柴 祥子

  埼玉医科大学ゲノム医学研究センター遺伝子情報制御部門

• 井上 聡

  埼玉医科大学ゲノム医学研究センター遺伝子情報制御部門:東京大学大学院医学系研究科抗加齢医学講座

書誌事項

タイトル別名

• Vitamin K and bone metabolism
• ビタミンKと骨代謝
• ビタミン K ト ホネ タイシャ

抄録

Vitamin K (VK) is a fat-soluble vitamin that is essential for blood coagulation as well as bone metabolism. VK consists of 3 forms due to the difference of side chains bound to naphtoquinone ring: VK_1 (phylloquinone), VK_2 (menaquinone) and, VK_3 (menadione). In Japan, VK_2 is clinically used as a therapeutic agent for osteoporosis. VK functions as a co-factor of VK-dependent γ-glutamyl carboxylase (GGCX) in mediating post-translational modifications. As GGCX-dependent γ-carboxylated (Gla) proteins expressed in bone, osteocalcin (OC) and matrix Gla protein (MGP) are known to play modulatory roles in bone metabolism. On the other hand, VK_2 also regulates the transcription of bone-related genes in osteoblasts through activating steroid X receptor (SXR)/pregnane X receptor (PXR), as well as enhancing the phosphorylation of protein kinase A (PKA). Recent studies have revealed that osteoblast-derived OC also exerts a hormone-like action that controls bone metabolism and energy metabolism. Overall, VK is an essential nutrient for bone metabolism through modulating multiple signaling pathways mediated by GGCX, SXR, PKA, and VK-dependent proteins

収録刊行物

• ビタミン

  ビタミン 88 (1), 18-24, 2014

  公益社団法人 日本ビタミン学会

キーワード

• Vitamin K
• bone metabolism
• GGCX
• SXR
• osteocalcin

詳細情報

• CRID: 1390001205700097920
• NII論文ID: 110009767428
• NII書誌ID: AN00207833
• DOI: 10.20632/vso.88.1_18
• ISSN: 2424080X
• ISSN: 0006386X
• NDL書誌ID: 025170575
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025170575
• Web Site: https://search.jamas.or.jp/link/ui/2014202393
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可