血中低カルボキシル化Matrix Gla Protein (ucMGP)濃度測定法の開発と血管のビタミンK栄養評価における有用性の検討

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  • Development of Assay Method for Plasma Concentration of Undercarboxylated Matrix Gla Protein (ucMGP), and Its Usefulness in Estimation of Vascular Vitamin K Status
  • チ ナカビク カルボキシルカ Matrix Gla Protein(ucMGP)ノウド ソクテイホウ ノ カイハツ ト ケッカン ノ ビタミン K エイヨウ ヒョウカ ニ オケル ユウヨウセイ ノ ケントウ

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Matrix Gla protein (MGP) is known as a potent vascular calcification inhibitor. MGP is a vitamin K dependent protein (VKDP) which is activated by gamma-carboxylation of Glu residues (Gla) in the presence of vitamin K. It is considered that plasma concentration of undercarboxylated MGP (ucMGP) will be useful as the marker for vascular vitamin K status. However, a method to accurately quantify the plasma ucMGP concentration has not been well established. In present study, we have developed the assay method for plasma concentration of ucMGP, and which could be concluded to be a useful marker in the estimation of vascular vitamin K status.

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  • ビタミン

    ビタミン 88 (3), 139-144, 2014

    公益社団法人 日本ビタミン学会

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