理想タンパク質構造の設計原理

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書誌事項

タイトル別名
  • Principles for Designing Ideal Protein Structures
  • リソウ タンパクシツ コウゾウ ノ セッケイ ゲンリ
  • 1P088 Principles for designing ideal protein structures(01F. Protein:Engineering,Poster)

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抄録

Protein folding occurs because the native interactions collectively outweigh non-native interactions, resulting in funnel-shaped energy landscapes. The funnel-shaped landscapes of natural proteins are rugged due to evolution for function or neutral drift. We describe an approach to designing ideal protein structures stabilized by consistent local and non-local interactions. The approach is based on rules relating local structures to tertiary motifs, which make possible the design of strongly funneled energy landscapes. Guided by these rules, we succeeded in designing five ideal alpha-beta protein structures with different topologies completely from scratch. These results illuminate how the folding funnels of natural proteins arise.<br>

収録刊行物

  • 生物物理

    生物物理 53 (4), 190-193, 2013

    一般社団法人 日本生物物理学会

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