D-アミノ酸関連酵素欠損に伴うほ乳類体内のD-アミノ酸含量変化(<特集>ビタミンB研究委員会平成25年度シンポジウム「ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究-ビタミン研究が切り拓く疾患生命科学のフロンティア」)

DOI Web Site

書誌事項

タイトル別名
  • Alteration of D-amino acid levels in the animals lacking enzymes relating D-amino acids
  • D-アミノ酸関連酵素欠損に伴うほ乳類体内のD-アミノ酸含量変化
  • D-アミノサン カンレン コウソ ケッソン ニ トモナウ ホニュウルイ タイナイ ノ D-アミノサン ガンリョウ ヘンカ

この論文をさがす

抄録

D-Amino-acid oxidase (DAO), which metabolizes neutral and basic D-amino acids including D-serine and D-alanine, and serine racemase (SRR), which catalyzes racemization of L-serine to D-serine, are regulatory factors of the intrinsic amounts of D-amino acids in mammals. Both enzymes have been demonstrated to have relation to neuronal diseases such as schizophrenia and amyotrophic lateral sclerosis via the regulation of the intrinsic amounts of neuromodulators of N-methyl-D-aspartate receptors, D-serine and D-alanine. Therefore, the regulators of DAO and SRR are proposed to become novel targets of drugs for changing the intrinsic amounts of D-serine and D-alanine, and the alterations of D-serine and D-alanine amounts following the changes of DAO and SRR activities are expected to be clarified. In this review, we have summarized recent works on the changes of D-serine and D-alanine amounts in mammalian brain tissues and physiological fluids with the decrease of activities of DAO and SRR. The highly sensitive and selective two-dimensional high-performance liquid chromatographic system for the determination of small amounts of D-amino acids in mammals has also been introduced.

収録刊行物

  • ビタミン

    ビタミン 88 (10), 515-523, 2014

    公益社団法人 日本ビタミン学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ