5 アテロコラーゲンスポンジを用いたヒト頬脂肪体由来の脱分化脂肪細胞と脂肪幹細胞の軟骨分化(第545回大阪歯科学会例会)

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  • 5 Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge

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The purpose of this study was to evaluate the Chondrocyte differentiation potential of dedifferentiated fat cells (DFATs) and adipose stem cells (ASCs) from the buccal fat pad (BFP) in an atelocollagen sponge. The gene expression levels of Chondrocyte differentiation markers were higher in DFATs than in ASCs cultured for 14 and 21 days, whereas protein expression levels were higher in DFATs at all time points tested for aggrecan. Additionally, the levels of the embryonic stem cell markers were higher in DFATs than in ASCs at 72 h. The extracellular matrix of both the cultured ASCs and DFATs was Alcianblue-positive and was also aggrecan-positive. Therefore, we think that BFP-derived DFATs are an ideal cell source for cartilage tissue engineering.

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  • 歯科医学

    歯科医学 78 (1), 17-18, 2015

    大阪歯科学会

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