P-50 茶カテキン結合ゼラチン担体の開発と骨形成能評価(インプラント・生体組織・毒性,一般講演(ポスター発表),第65回日本歯科理工学会学術講演会)

本田 義知, 橋本 典也, 今井 弘一, 清水谷 公成

P-50 茶カテキン結合ゼラチン担体の開発と骨形成能評価(インプラント・生体組織・毒性,一般講演(ポスター発表),第65回日本歯科理工学会学術講演会)

本田義知

大歯大・中歯研
橋本典也

大歯大・理工
今井弘一

大歯大・理工
清水谷公成

大歯大・中歯研大歯大・放射線

書誌事項

タイトル別名

P-50 Development of catechin-binding gelatin complex as bone substitute material

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抄録

Epigallocatechin gallate (EGCG) isolated from green tea is known to show various pharmacological effects. Nevertheless, its application in regenerative medicine has been limited due to its poor chemical reaction to other substances. Here we demonstrated that the EGCG-binding gelatin (EGCG-Gel) prepared in the aqueous chemical synthesis facilitated bone formation in the critical size defect of mouse calvaria. The EGCG-Gel induced osteogenic differentiation to mouse mesenchymal stem cell line (D1 cell). These results indicated that EGCG-Gels containing adequate amount of EGCG is likely to be a prospective bone substitute material.