前眼部螢光測定装置による水晶体自発螢光の生体内定量

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  • Quantification of Autofluorescence in Human Lens
  • ゼンガンブ ケイコウ ソクテイ ソウチ ニ ヨル スイショウタイ ジハツ ケイコウ ノ セイタイ ナイ テイリョウ

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type:原著

前眼部螢光測定装置を改良し,励起側中心波長Ex 340 nm(260-390 nm),螢光側中心波長Em 440 nm(400-710 nm)で白内障のない水晶体の自発螢光をin vivoで測定した.水晶体自発螢光値の年代別変化は,10歳代38.7±8.4(photoncount/msec),20歳代56.0±15.4,30歳代74.4±14.4,40歳代94.2±28.6,50歳代115.3±27.0,60歳代113.8±32.3で,50歳代まで加齢とともに増加し,水晶体の自発螢光は年齢と有意な正の相関を示した(r=0.76,p<0.01).水晶体の自発螢光値の増加は加齢現象を示す指標の一つであり,本測定装置により水晶体の加齢変化を非侵襲かつ簡便に測定できると考えられた.

To investigate changes in lens autofluorescence with aging, we measured the in vivo autofluorescence of non-cataract lenses using an anterior fluorophotometer. The FL-500 anterior fluorophotometer is a non-invasive, simplified quantification measuring device with improved filters of optimum wavelengths to measure lens autofluorescence(excitation filter:center 340 nm(260-390 nm), emission filter: center 440 nm(400-710 nm)). The subjects were 410 non-cataract eyes from volunteers aged 8-69 without systemic disease such as diabetes. Autofluorescence was compared between lenses grouped according to age(decades). Thus, autofluorescence was 38.7±8.4(photoncount/msec) for the second decade of life(10-19 years old), 56.0±15.4 for the third(20-29 years old), 74.4±14.4 for the fourth (30-39 years old), 94.2±28.6 for the fifth(40-49 years old), 115.3±27.0 for the sixth(50-59 years old), and 113.8±32.3 for the seventh(60-69 years old). These measurements increased significantly from the first to the fifth decade(p< 0.01), so lens autofluorescence was significantly correlated with age(r=0.76, p<0.01). In conclusion, the autofluorescence of non-cataract lenses increases with age from 10 to 50 years, and therefore represents a good indication of aging.

identifier:4

identifier:KJ00009895941

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