W054001 Current status of ischemic reperfusion injury in clinical organ preservation and progress of machine perfusion preservation

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  • Matsuno N
    Department of Gastroenterologic and Transplant Surgery:Asahikawa Medical University:Tokyo Metropolitan University, Mechanical Engineering
  • Obara H
    Asahikawa Medical University
  • Enosawa S
    Asahikawa Medical University
  • 水沼 博
    国立大学法人旭川医科大学外科学講座消化器病態外科学分野
  • Furukawa H
    Asahikawa Medical University

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Other Title
  • W054001 移植医療における虚血再灌流障害と持続灌流型臓器保存の進歩([W05400]流体工学部門,バイオエンジニアリング部門企画,血液の視える化研究(血視研))

Abstract

The use of expanded criteria donor (ECD) and donation after circulatory death (DCD) donor is one of important way of resolution for the critical shortage of diseased donor graft. However, the ischemic damage of these grafts jeopardizes organ viability during cold storage. Simple cold storage is the most widely used form of preservation in clinical practice even for these marginal grafts. However, it is questionable whether this method is able to prevent from deterioration of ECD or DCD organ quality. Although, the fact that hypothermic machine perfusion might be superior to static cold preservation in reducing the high incident of delayed graft function, marginal grafts are exposed to warm and additional hypothermia induced damage. This review describes current concepts and development of machine perfusion preservation for marginal graft. The beneficial effects of normothermic machine perfusion as a new perspective preservation for DCD grafts also are introduced. The development of novel preservation technology and science to recover from severe ischemic damage must be improved in marginal donor era.

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