20714 弾性担体を利用した再生血管の構築

• 小松 寛

  東大院

• 渡辺 翔太

  東大院

• 小林 一穂

  東大

• 増本 憲泰

  日工大

• 戸張 悦男

  日工大

• 牛田 多加志

  東大

• 古川 克子

  東大

書誌事項

タイトル別名

• 20714 A Template for Manuscript Preparation

抄録

Amount of blood vessel diseases has been increasing. Artificial vascular grafts are widely used for transplantation treatment, but they have problems such as clot generation and tissue rejection. Tissue engineering is considered as an excellent method for making artificial vascular grafts. The previous study showed that cyclic mechanical uniaxial stretch caused differentiation of mesenchymal stem cells to smooth muscle cells. The tubular scaffold in this study has elasticity that can withstand 40% of natural blood pressure. This was tested with a created bioreactor for tubular scaffold that is able to control pressure and flow rate with the use of syringe pump. Mesenchymal stem cells were seeded on the scaffolds and cultured for 3days in vitro. The differentiation to smooth muscle cell was confirmed with the use of Real-time PCR. Overall, this scaffold for vascular graft and bioreactor system were shown to be useful in the reconstruction of blood vessels.

収録刊行物

• 日本機械学会関東支部総会講演会講演論文集

  日本機械学会関東支部総会講演会講演論文集 2015.21 (0), _20714-1_-_20714-2_, 2015

  一般社団法人 日本機械学会

キーワード

• Tissue Engineering
• scaffold
• Blood vessel
• Mechanical stress
• differentiation

詳細情報

• CRID: 1390282680825736576
• NII論文ID: 110009948366
• DOI: 10.1299/jsmekanto.2015.21._20714-1_
• ISSN: 24242691
• Web Site: https://www.jstage.jst.go.jp/article/jsmekanto/2015.21/0/2015.21__20714-1_/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可