E111 流動場を利用した巨大単膜リポソームの生成条件に関する研究(OS-4:バイオトランスポートと生体熱工学)

• 高野 清

  東大生研

• 白樫 了

  東大生研

書誌事項

タイトル別名

• E111 Study on Conditions for Forming Giant Unilamellar Vesicles under Flow Field

抄録

We performed the experiment in Giant Unilamellar Vesicles (GUV)-mass production that utilizes the mechanical oscillation on the silicone substrate with the rehydrated patterned-lipid-layers. The effect of the electric conductivity of rehydrating solution on GUVs' productivity was evaluated by measuring the density and the diameter distribution of GUVs that were produced in an isotonic (300 mOsmol/kg) mixture of D-mannitol (low conductivity) and KCl (or PBS) (high conductivity). It is found that GUVs are produced only by under the flow field, although the productivity of GUV becomes extremely lower as the electric conductivity becomes higher. From these results, we clarify that the electric conductivity and the flow field in the solution are important for the mass-GUY production.

収録刊行物

• 熱工学コンファレンス講演論文集

  熱工学コンファレンス講演論文集 2013 (0), 131-132, 2013

  一般社団法人 日本機械学会

キーワード

• GUY
• Unilamellar Vesicle
• Liposome
• Flow Field

詳細情報

• CRID: 1390001205880067328
• NII論文ID: 110009955657
• DOI: 10.1299/jsmeted.2013.131
• ISSN: 2424290X
• Web Site: https://www.jstage.jst.go.jp/article/jsmeted/2013/0/2013_131/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可