レチノール結合タンパク質群によるビタミンAの輸送,貯蔵,代謝の調節とその意義

• 目崎 喜弘

  秋田大学大学院医学系研究科細胞生物学講座

書誌事項

タイトル別名

• Modulation of transport, storage and metabolism of vitamin A by retinol-binding proteins and its physiological significance
• レチノール ケツゴウ タンパクシツグン ニ ヨル ビタミン A ノ ユソウ,チョゾウ,タイシャ ノ チョウセツ ト ソノ イギ

抄録

Vitamin A alcohol (retinol) binds to a family of proteins called retinol-binding proteins in order to neutralize hydrophobicity of the retinol. Plasma retinol-binding protein (RBP), which is also called RBP4 in recent classification, is an extracellular binding protein for retinol, and cellular retinol-binding protein (CRBP) I and II are intracellular binding proteins for retinol. These retinol-binding proteins also affect transport, storage and metabolism of vitamin A through various mechanisms. For example, retinol being transported in blood escapes renal excretion by binding to RBP and transthyretin. Another example is that retinol efflux and influx are regulated by stimulated by retinoic acid 6 (STRA6), a membrane receptor for RBP. Thirdly, enzymatic activities of intracellular retinol-esterifying enzymes, lecithin:retinol acyltransferase and acyl-CoA:retinol acyltransferase are modulated differently by CRBPs. The aspects of these phenomena are described based on the conformational findings of RBP and CRBPs.

収録刊行物

• ビタミン

  ビタミン 89 (5-6), 271-274, 2015

  公益社団法人 日本ビタミン学会

キーワード

• vitamin A
• plasma retinol-binding protein
• cellular retinol-binding protein
• lecithin: retinol acyltransferase
• acyl-CoA:retinol acyltransferase

詳細情報

• CRID: 1390282680677536128
• NII論文ID: 110009969587
• NII書誌ID: AN00207833
• DOI: 10.20632/vso.89.5-6_271
• ISSN: 2424080X
• ISSN: 0006386X
• NDL書誌ID: 026568208
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026568208
• Web Site: https://search.jamas.or.jp/link/ui/2015289455
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可