P-8 シソ科植物Scutellaria coleifolia地上部の成分研究(ポスター発表の部)

• 栗本 慎一郎

  徳大院薬

• 普 建新

  中国科学院昆明植物研

• 孫 漢董

  中国科学院昆明植物研

• 高石 喜久

  徳大院薬

• 柏田 良樹

  徳大院薬

書誌事項

タイトル別名

• P-8 Study on the constituents of the aerial parts of Scutellaria coleifolia (Lamiaceae)(Poster Presentation)

抄録

Scutellaria plants belong to the Lamiaceae family and include about 350 species. They are widely distributed in template zone and tropical zone of Europe, North America and East Asia and have been used as traditional medicines in many countries. For example, roots of them are used for removing fever and resolution in Chinese Traditional Medicines, while aerial parts of them are used as sedative and antispasmodic in United States. In previous study, flavonoids and diterpenes were mainly isolated from the Scutellaria plants, some of which showed biological activities such as anti-cancer, anti-inflammatory and anti-feedant activity and so on. As part of our investigation for searching new drug seeds, we have studied the chemical constituents of Scutellaria coleifolia. S. coleifolia were collected in Sichuan province, China, in August 2011. The air dried aerial parts of this plant (3.0 kg) were crushed and extracted three times with 70 % aqueous acetone for 72 hr at room temperature. The extract was successively partitioned with EtOAc, n-BuOH and H_2O. The EtOAc-soluble fraction (130.0 g) was separated by repeated column chromatography (silica gel, Sephadex LH-20, MCI gel CHP2OP, ODS MPLC, ODS HPLC) to give 14 new compounds (1-14), along with 4 known compounds (15-18). The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic analyses. Compounds 1 and 2 were sesterterpenes with a γ-lactone moiety, structurally similar to manoalide derivatives. Our study provided the first examples of manoalide derivatives isolated from higher plants. Compounds 5-14 were neo-clerodane type diterpenes with a 13-spiro-15,16-γ-lactone structure, which are especially contained Scutellaria plants. The structure elucidation and biological activities of isolated compounds will be presented.

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 54 (0), 483-488, 2012

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390001206079550720
• NII論文ID: 110010013874
• DOI: 10.24496/tennenyuki.54.0_483
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可