Chronic Psychological Stress as a Risk Factor of Osteoporosis

• AZUMA Kagaku

  Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan

• ADACHI Yasuhiro

  Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan

• HAYASHI Haruki

  Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan

• KUBO Kin-Ya

  Seijoh University Graduate School of Health Care Studies, Japan

Bibliographic Information

Other Title

• 骨粗鬆症の危険因子としての慢性の精神的ストレス

Abstract

Osteoporosis, the most common metabolic skeletal disease, is characterized by decreased bone mass and deteriorated bone quality, leading to increased fracture risk. With the aging of the population, osteoporotic fracture is an important public health issue. Organisms are constantly exposed to various stressful stimuli that affect physiological processes. Recent studies showed that chronic psychological stress is a risk factor for osteoporosis by various signaling pathways. The purpose of this article is to review the recent progress of the association between chronic psychological stress and osteoporosis. Increasing evidence confirms the physiological importance of the central nervous system, especially the hypothalamus, in the regulation of bone metabolism. Both animal and human studies indicate that chronic psychological stress induces a decrease of bone mass and deterioration of bone quality by influencing the hypothalamic-pituitary-adrenocortical (HPA) axis, sympathetic nervous system, and other endocrine, immune factors. Active mastication, proven to be an effective stress-coping behavior, can attenuate stress-induced neuroendocrine responses and ameliorate stress-induced bone loss. Therefore, active mastication may represent a useful approach in preventing and/or treating chronic stress-associated osteoporosis. We also discuss several potential mechanisms involved in the interaction between chronic stress, mastication and osteoporosis. Chronic stress activates the HPA axis and sympathetic nervous system, suppresses the secretion of gonadal hormone and growth hormone, and increases inflammatory cytokines, eventually leading to bone loss by inhibiting bone formation and stimulating bone resorption.

Journal

• Journal of UOEH

  Journal of UOEH 37 (4), 245-253, 2015

  The University of Occupational and Environmental Health, Japan

Keywords

• chronic psychological stress
• hypothalamus
• mastication
• osteoporosis
• sympathetic nervous system

Details

• CRID: 1390001205085084032
• NII Article ID: 110010015402
• NII Book ID: AN0009832X
• DOI: 10.7888/juoeh.37.245
• ISSN: 21872864
• ISSN: 0387821X
• NDL BIB ID: 027003799
• PubMed: 26667192
• Web Site: https://uoeh-u.repo.nii.ac.jp/records/722
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027003799
• Web Site: https://www.jstage.jst.go.jp/article/juoeh/37/4/37_245/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016219440
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed