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- 宮澤 陽夫
- 東北大学未来科学技術共同研究センター:東北大学大学院農学研究科
書誌事項
- タイトル別名
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- Antiangiogenic and anticancer functions of tocotrienol and its application for food products
- トコトリエノール ノ シュヨウセイ コウケッカン シンセイ サヨウ ト ショクヒン オウヨウ ニ カンスル ケンキュウ
この論文をさがす
抄録
The antiangiogenic and anticancer functions of tocotrienol (an unsaturated vitamin E) were discovered, and their molecular mechanisms were clarified in studies using cell cultures and experimental animals. Tocotrienol inhibits hypoxia-induced vascular endothelial growth factor secretion, and suppresses vascular endothelial growth factor and interlukin-8 expression at both mRNA and protein levels in tumor cells. The physiological functions of tocotrienol based on its intestinal absorption, its tissue organ distribution, its skin anti-inflammation and its improved lipid metabolism were also explained. The tocotrienol-rich rice plant strain was established, and the daily intake of tocotrienol in Japanese population and the safety of dietary intake of tocotrienol were confirmed. These investigations indicate the physiological significance of tocotrienol ingestion as a fat-soluble vitamin and a functional component in food products.
収録刊行物
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- ビタミン
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ビタミン 90 (2), 68-76, 2016
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205785990528
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- NII論文ID
- 110010039884
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 027133326
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可