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- 加来田 博貴
- 岡山大学大学院医歯薬学総合研究科
書誌事項
- タイトル別名
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- Discovery Research of Drugs Targeting Retinoid X Receptors
- レチノイド X ジュヨウタイ オ ヒョウテキ ト シタ ソウヤク ニ カンスル ケンキュウ
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抄録
So-called modern diseases such as type 2 diabetes, cancer, Alzheimer's disease and others are closely related to glucose and lipid metabolism. Therefore, improvement of the internal environment might be an effective therapeutic approach for these modern diseases. Since retinoid X receptors (RXRs), which are nuclear receptors that act as ligand-dependent transcription factors, function as homodimers or heterodimers with other nuclear receptors, a wide variety of biological effects and therapeutic effects on the above described diseases can be expected. However, the past RXR agonists cause serious side effects such as blood triglyceride elevation, hypothyroidism and others. Our research group has been advocating a strategy of "revival drug discovery" to revive abandoned drug targets based on the idea to avoid the side effects of drugs. In this review, our past discovery research of drugs targeting RXRs will be introduced.
収録刊行物
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- ビタミン
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ビタミン 90 (3), 101-108, 2016
公益社団法人 日本ビタミン学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001205785927040
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- NII論文ID
- 110010043281
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 027214028
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可