Exogenous S100A4 Protein Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice by Reducing the Levels of Fibroblast Growth Factors

• Mineaki, Watanabe

• Hirokuni, Hirata

• Masamitsu, Tatewaki

• Kenya, Kohyama

• Kumiya, Sugiyama

• Yasutsugu, Fukushima

• Yoshiki, Ishii

• Takeshi, Fukuda

• Masafumi, Arima

抄録

type:Original

Background and objective:The calcium-binding protein S100A4 belongs to the S100 family and is involved in fibrotic and inflammatory processes, in which tissue remodeling, cell motility, and epithelialmesenchymal transition play major roles. Cytoplasmic S100A4 is a marker of lung fibroblasts in pulmonary fibrosis;however, the effects of exogenous S100A4 on fibrotic and inflammatory processes in pulmonary fibrosis are unclear. This study examined the effects of exogenous S100A4 protein in mice with bleomycin-induced pulmonary fibrosis.Methods:Bleomycin was administered to mice by intratracheal instillation on day 1. Intratracheal S100A4 protein was administered 4 times after bleomycin treatment. Bronchoalveolar lavage fluid was obtained and lung histological examinations were performed on day 14 after bleomycin administration. Lung tissue was homogenized on the same day to assess the mRNA expression of cytokines, fibroblast growth factors, and S100A4.Results:Unexpectedly, we observed that the administration of exogenous S100A4 protein apparently reduced lung fibrosis in bleomycin-treated mice. In addition, the levels of lymphocyte accumulation and insulin-like growth factor-1 mRNA were significantly reduced in bleomycin-treated lung by S100A4 administration.Conclusions:Exogenous S100A4 protein attenuates bleomycin-induced pulmonary fibrosis in mice by reducing lymphocyte function and the levels of fibroblast growth factors.

identifier:2

identifier:KJ00010247939

収録刊行物

• Dokkyo journal of medical sciences

  Dokkyo journal of medical sciences 43 (2), 105-113, 2016-07-25

キーワード

• S100A4
• Bleomycin-treated Mice
• Pulmonary Fibrosis
• Fibroblast Growth Factors

詳細情報

• CRID: 1050001338514544896
• NII論文ID: 110010047451
• NII書誌ID: AA00629581
• ISSN: 03855023
• Web Site: http://id.nii.ac.jp/1199/00001294/
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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