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- 菊川 詢也
- 東大院
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- TH Wu Andy
- 東大院
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- 牛田 多加志
- 東大
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- 古川 克子
- 東大
書誌事項
- タイトル別名
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- OS1404 The Effect of Cyclic Hydrostatic Pressure on Endochondral Ossification in Synovial Joint Development
抄録
The human body is capable of sensing and adapting to mechanical stimuli, especially the musculoskeletal system. For example, joints in the knee undertake high loads up to several times of the body weight during activities such as running and jumping. The tissue responds to such stress by remodeling itself to better withstand the load. Synovial joints are functionally and structurally immature post-birth, where the epiphysis is composed almost entirely of cartilaginous tissue. As the joint matures, chondrocytes in this region become hypertrophic and the tissue undergoes endochondral ossification where the cartilaginous matrix is mineralized into bone tissue. Mechanical stimulation, such as hydrostatic pressure (HP), is hypothesized to be involved in this process. In this study, we isolated synovial joints from juvenile rats and applied HP ex vivo to examine its effect on joint maturation. From histological analysis and quantification of ECM proteins, we observed that HP can accelerate endochondral ossification.
収録刊行物
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- 日本機械学会関東支部総会講演会講演論文集
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日本機械学会関東支部総会講演会講演論文集 2016.22 (0), _OS1404-1_-_OS1404-2_, 2016
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390282680827374464
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- NII論文ID
- 110010050167
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- ISSN
- 24242691
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可