2D33 温熱刺激による腱細胞炎症性応答における細胞間物質輸送の寄与

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  • 2D33 Contribution of intercellular communications to inflammatory responses of tenocytes to thermal stimulation

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Tendinopathy has been one of major health concerns in orthopaedic surgery, not only for active athletes but also for others like office workers. Although the exact etiology of tendinopathy has yet to be elucidated, it has been demonstrated that tendon core temperature elevated up to 43 to 45 degree Celsius when humans or racehorses are subjected to extensive exercises (harsh running). A long exposure to such high temperature could induce cell death. However, effects of the exposure to the high temperature for relatively short terms (simulating running activity) on tenocyte functions are still not understood. Therefore, the present study was performed to investigate how tenocyte anabolism and catabolism are altered by a short thermal stimulation. In addition, the present study tested a hypothesis that such alterations of tenocyte functions are dependent in the presence of gap junction intercellular communication (GJIC). It was demonstrated that tenocyte GJIC was not significantly altered by a 30 minutes exposure to 43 degree. However, catabolic and inflammatory gene expressions were significantly upregulated following a 24 h post-heating culture period. With the presence of GJ blocker, upregulation of catabolic genes by the thermal stimulation was inhibited, although inflammatory gene expression was further enhanced. These results may indicate that GJIC in part contribute to alterations in tenocyte functions in response to thermal stimulation in a complicated manner.

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