Selective introduction of a fluorine atom into carbohydrates and a nucleoside by ring-opening fluorination reaction of epoxides

• Akiyama, Yuriko

• Hiramatsu, Chiharu

• Fukuhara, Tsuyoshi

• Hara, Shoji

抄録

Ring-opening fluorination reactions of epoxides using tetrabutylammonium bifluoride (TBABF)-KHF2, or Et3N-3HF under microwave irradiation were applied for the introduction of a fluorine atom into the carbohydrate molecules. When TBABF-KHF2 was used as the fluorination reagent, a fluorine atom was introduced regioselectively and various functional groups can tolerate the conditions. When Et3N-3HF was used under microwave irradiation, the reaction time could be remarkably shortened compared with the conventional oil-bath heating.

収録刊行物

• Journal of Fluorine Chemistry

  Journal of Fluorine Chemistry 127 (7), 920-923, 2006-07

  Elsevier

キーワード

• Fluorinated carbohydrates
• Ring-opening fluorination
• Epoxides
• Microwave

詳細情報

• CRID: 1050282813955832832
• NII論文ID: 120000955044
• HANDLE: 2115/14466
• ISSN: 00221139
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles