BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1

• Ikeda, Osamu

• Sekine, Yuichi

• Mizushima, Akihiro

• Oritani, Kenji

• Yasui, Teruhito

• Fujimuro, Masahiro

• Muromoto, Ryuta

• Nanbo, Asuka

• Matsuda, Tadashi

抄録

Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-κB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-κB activation and up-regulates IL-6 mRNA expression and IκB degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).

収録刊行物

• FEBS Letters

  FEBS Letters 583 (10), 1567-1574, 2009-05-19

  Elsevier

キーワード

• EBV
• LMP1
• BS69
• NF-κB
• TRADD

詳細情報

• CRID: 1050845763931013632
• NII論文ID: 120001274621
• NII書誌ID: AA00642943
• HANDLE: 2115/38441
• ISSN: 00145793
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles