消化管運動に対するメリロートエキスの作用

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  • Effect of Melilotus Extract on Mammalian Gastrointestinal Motility

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Effect of the plant extract （Mel-ext） derived from Melilotus officinalis on mammalian gastrointestinal motility was investigated. Gastrointestinal transit of charcoal meal in mice was facilitated by the pretreatmemt with Melext or coumarin （a dose which is comparable to its content in the extract）, which were given orally 90 min before the charcoal meal. In rabbits, venous administration of Mel-ext repeatedly resulted in a transitory inhibition of the motility and a decrease of muscle tone in the gastrointestinal tract （stomach, ileum and colon）. The spontaneous contraction of the isolated rabbit ileum was inhibited by Mel-ext and coumarin. Dose-response curve for acetylcholine in isolated guinea pig ileum shifted to the right in the presence of Mel-ext, but the curve for histamine was not affected by the extract. The contraction of the isolated guinea pig ileum induced by transmural electrical stimulation was inhibited by Mel-ext and coumarin and these inhibitory effects were slightly antagonized by naloxone. From the above results, it seems likely that the transitory and repetitive inhibition of motility and the decrease of gastrointestinal muscle tone induced by Mel-ext or coumarin may greatly contribute to facilitate the gastrointestinal transit of contents. Effects of the extract may be brought about by coumarin. Also the present results suggest a possibility that the site of action of Mel-ext and coumarin may be located at the nerve plexus of the gastrointestinal wall and/or gastrointestinal smooth muscle.

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