[原著］Production of bacteriocins by Clostridium scindens and some of their properties

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Twenty-three strains of Clostridium scindens isolated from 11 human feces samples and one reference strain were examined for both bacteriocin production and bacteriocin susceptibility. Out of these, 10 strains were found to produce bacteriocins, and another 10 strains were sensitive to the bacteriocins. The bacteriocin-producing strains were resistant to their own bacteriocin as well as bacteriocin produced by other strains. Six strains were sensitive to all tested bacteriocins. Four of the strains tested were insensitive to all bacteriocins and produced no bactenocin. The physicochemical properties of three bacteriocins produced by strains O-51, Y-1113 and O-161 were similar, and were mitomycin C inducible, trypsin resistant and heat-labile. Sensitivity to the bacteriocins was confined to other strains of C. scindens, Eubacterium species VPl 12708, Eubacterium species strains C-25 and Peptostreptococcus anaerobius PL-9; the other gram-positive and gram-negative bacteria tested for sensitivity were not affected by the bactenocins. Crude bacteriocins killed sensitive cells rapidly but cell lysis did not appear to be involved

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