書誌事項
- タイトル別名
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- Laboratory and clinical evaluation on carbenicillin
- Carbenicillin アルファ-carboxybenzyl penicillin ニ カンスル キソテキ , リンショウテキ ケントウ
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抄録
The report deals with the laboratory and clinical assessment of Carbenicillin (CB-PC) on urinary tract infection. The results obtained were as follows. 1) The MIC of CB-PC against 268 strains of bacteria isolated from urinary tract infection were determined by plate dilution method. The MIC were less than 12.5 mcg/dl in 25% of Staphylococcus aureus, 66.1 % of Staphylococcus epidermidis, 26.7 % of Enterococcus, 5 % of Klebsiella, 38.1 % of E. coli, 37.5 % of Proteus vulgaris, 87.5 % of Proteus mirabilis, 66.7 % of Citrobacter, 14.3 % of Cloaca, 66.7% of Morganella, 50 % of Alcaligenes vulgaris and all of Providencia. The MIC of Pseudomonas aeruginosa ranged in 25 to 250 mcg/dl. As compared with AB-PC, CB-PC was more active against Klebsiella, Proteus vulgaris and Pseudomonas aeruginosa and less active against Staphylococcus. 2) Serum concentration following an intramuscular administration of 1.0 gm in three healthy adults reached the peak level of 20.8 mcg/ml in average after 30 minutes. Urinary recovery was 49 % and concentration was 1.227 mcg/ml for 6 hours. 3) Rat tissue assays were performed 30 minutes following an intramuscular injection of 20 mg per kg body weight and the kidney had the highest activity of 51.3 mcg/g in average of three rats. Other tissues were in the following order, liver, blood, lung and spleen. 4) Of 9 patients with secondary infection by Gram-negative rod after surgical procedures, six were treated effectively receiving parenterally 4.0 gm a day for 5 to 7 days.
収録刊行物
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- 泌尿器科紀要
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泌尿器科紀要 16 (11), 683-687, 1970-11
京都大学医学部泌尿器科学教室
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詳細情報 詳細情報について
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- CRID
- 1050845760610059776
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- NII論文ID
- 120002232396
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- NII書誌ID
- AN00208315
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- ISSN
- 00181994
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- HANDLE
- 2433/121189
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- NDL書誌ID
- 8425711
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
- CiNii Articles