Dogs refractory to compound 48/80 and sinomenine

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<p>Five (21 per cent) out of 24 mongrel dogs were found to be refractory to compound 48/80 and also to sinomenine (cross-tolerance). These nonreactor dogs responded normally to PVP and tween 20 and showed normal sensitivity to histamine. The incidence was similar in both sexes. Mechanisms of this type refractoriness were discussed.</p>

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