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<p>Carcinogenic effect of N, N'-dimethylnitrosourea (DMNU) on mice and hamsters was studied. Repeated subcutaneous injections of DMNU resulted in the induction of malignant lymphomas with an incidence of 100 per cent in adult C3HjBifBjKi mice and induced malignant tumors of forestomach, mammary gland and uterus with a high incidence in adult hamsters. Control animals showed no pathological changes. Electron microscopy revealed the presence of murine type C virus particles in some of the tissues examined. Many type C virus particles were found in a transplant of DMNU.induced malig. nant lymphoma. Some type C virus particles were shown in malignant lymphomas and lymph nodes of malignant lymphoma-bearing mice. A very small number of type C virus particles were observed in thymus of control mice and bone marrow of a malignant lymphoma.bearing mouse. A few particles, quite similar to murine type C virus particles, were detected in DMNU.induced mammary adenocarcinoma of hamster. No virus-like particles were seen in mammary glands of control hamsters. Whether these particles are merely passengers or are playing a significant role in the carcinogenesis of these tumors remains to be determined.</p>
収録刊行物
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- Acta Medica Okayama
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Acta Medica Okayama 28 (5), 333-351, 1974-10
Okayama University Medical School
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詳細情報 詳細情報について
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- CRID
- 1390572174500909312
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- NII論文ID
- 120002311642
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- NII書誌ID
- AA00508441
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- ISSN
- 0386300X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles