Carcinogenesis in tissue culture. 22. Malignant transformation of cloned rat liver cells treated in culture with 4-dimethylaminoazobenzene and properties of the transformed cells

• Miyahara Y.

• Namba M.

• Sato J.

抄録

Cultured rat liver cells which were cloned from a single cell were transformed into malignant cells by a chemical carcinogen, 4-dimethylaminoazobenzene (DAB). The DAB-transformed cells produced tumors when back-transplanted into new-born rats but the carcinogen-untreated control cells did not. Characteristics of the transformed liver cells were compared to those of DAB-untreated control cells in regard to the morphology, the consumption of DAB from the culture medium by the cells, the incorporation of 3H.DAB into the cells, and the aggregate.forming ability of the cells in rotation culture. The results showed that no significant parameter of malig. nant transformation in culture was detectable except the tumorigenicity of the transformed cells upon the inoculation into animals.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 28 (2), 99-109, 1974-04

  Okayama University Medical School

詳細情報

• CRID: 1390290699524083456
• NII論文ID: 120002311823
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/32703
• Web Site: https://ousar.lib.okayama-u.ac.jp/32703
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles