Mechanism of proteinuria in nephrotic syndrome.

• Ota Zensuke

• Shikata Kenichi

• Ota Kosuke

抄録

We developed a "tissue negative staining method" to observe the molecular-level ultrastructure in situ in any portion of the ultrathin sections routinely prepared for electron microscopy. This method was used in electron microscopy of the glomerular basement membranes (GBM). The GBM in patients with nephrotic syndrome was discovered to possess a tunnel structure, designated as "nephrotic tunnel", with lumen large enough to allow free passage of protein molecules. This tunnel seemed to be involved in the etiology of nephrotic syndrome. This new method appears to be applicable to a variety of purposes in biological studies.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 46 (6), 483-487, 1992-12

  Okayama University Medical School

キーワード

• mechanism
• proteinuria
• nephrotic syndrome
• electron microscopy
• negative staining

詳細情報

• CRID: 1390853649511119488
• NII論文ID: 10010606168
• NII論文ID: 120002311922
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/32632
• PubMed: 1485544
• Web Site: https://ousar.lib.okayama-u.ac.jp/32632
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles