Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia
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<p>A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. We made a clinical diagnosis of invasive pulmonary aspergillosis (IPA) based on a consolidation in the right upper lung field on a chest radiograph as well as a high level of serum beta-D-glucan (with no evidence of tuberculosis and candidiasis). We changed her treatment from micafungin to voriconazole. Later, we discovered an air-crescent sign by CT scan that supported the diagnosis of IPA. Following voriconazole treatment, clinical symptoms ceased and abnormal chest shadows improved gradually and concurrently with a recovery of neutrophils. IPA must be considered in immunocompromised patients with pulmonary infiltrates who do not respond to broad-spectrum antibiotics. Serological tests and CT findings can aid in early diagnosis of IPA, which, along with treatment for IPA, will improve clinical outcomes.</p>
収録刊行物
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- Acta Medica Okayama
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Acta Medica Okayama 63 (4), 213-216, 2009-08
Okayama University Medical School
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詳細情報 詳細情報について
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- CRID
- 1390009224546740864
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- NII論文ID
- 120002312639
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- NII書誌ID
- AA00508441
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- ISSN
- 0386300X
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- PubMed
- 19727206
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- PubMed
- CiNii Articles