Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma

• Nakajima, Katsuyuki

• Kobayashi, Junji

• Mabuchi, Hiroshi

• Nakano, T.

• Tokita, Yoshiharu

• Nagamine, T.

• Imamura, S.

• Ai, Masumi

• Otokozawa, Seiko

• Schaefer, E. F.

抄録

金沢大学医学系研究科

Background: The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma. Methods: ANGPTL3, LPL activity, HTGL activity, RLP-C and RLP-TG and small, dense LDL-cholesterol (sd LDL-C) were measured in 20 overweight and obese subjects in the fasting and postprandial states. Results: Plasma TG, RLP-C, RLP-TG and sd LDL-C were inversely correlated with LPL activity both in the fasting and postprandial states, but not correlated with HTGL activity and ANGPTL3. However, plasma HDL-C was positively correlated with LPL activity both in the fasting and postprandial states, while inversely correlated with HTGL activity. ANGPTL3 was inversely correlated with HTGL activity both in the fasting and postprandial states, but not correlated with LPL activity. Conclusion: HTGL plays a major role in HDL metabolism, but not RLP metabolism. These findings suggest that ANGPTL3 is strongly associated with the inhibition of HTGL activity and regulates HDL metabolism, but not associated with the inhibition of LPL activity for the metabolism of RLPs in human plasma.

収録刊行物

• Annals of Clinical Biochemistry

  Annals of Clinical Biochemistry 47 (5), 423-431, 2010-09-01

  Wiley-Blackwell

詳細情報

• CRID: 1050845760880945024
• NII論文ID: 120002519245
• NII書誌ID: AA00532333
• ISSN: 00045632
• Web Site: http://hdl.handle.net/2297/25429
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles