書誌事項
- タイトル別名
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- Significance of a Simple Assay of Urine Telomerase Activity for the Detection of Bladder Cancer
- ボウコウガン ニ オケル ニョウ テロメラーゼ カッセイ カンイ ソクテイホウ ノ ユウヨウセイ
この論文をさがす
抄録
We developed a simple urine telomerase activity assay by a modification of the TeloTAGGG telomerase polymerase chain reaction (PCR) enzyme-linked immunosorbent assay kit. We conjugated digoxygenin (DIG) with the CX primer of omitting hybridization of PCR products and DIG-labeled probe. The sensitivity and specificity of bladder cancer diagnosis on 100 patients with bladder cancer and 25 healthy volunteers using the simple urine telomerase activity measurement were 81% and 92%, respectively. The positive rate for bladder cancer by the present assay system was affected by neither tumor grade nor invasiveness. The diagnostic potential of the present method is superior to the conventional urine telomerase assay kit and urine nuclear matrix protein-22 (NMP22). The present method is simple, and can be used for mass screening of bladder cancer.
収録刊行物
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- 泌尿器科紀要
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泌尿器科紀要 56 (10), 551-557, 2010-10
泌尿器科紀要刊行会
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詳細情報 詳細情報について
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- CRID
- 1050001202065427584
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- NII論文ID
- 120002576706
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- NII書誌ID
- AN00208315
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- ISSN
- 00181994
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- HANDLE
- 2433/130819
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- NDL書誌ID
- 10858930
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
- CiNii Articles
- KAKEN