Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses

• Koizumi, Hirokazu

• Hashimoto, Masao

• Fujiwara, Mamoru

• Murakoshi, Hayato

• Chikata, Takayuki

• Ali Borghan, Mohamed

• Hachiya, Atsuko

• Kawashima, Yuka

• Takata, Hiroshi

• Ueno, Takamasa

• Oka, Shinichi

• Takiguchi, Masafumi

• 小泉, 寛和

• 端本, 昌夫

• 藤原, 守

• 村越, 勇人

• 蜂谷, 敦子

• 川島, 夕佳

• 高田, 比呂志

• 上野, 貴将

• 岡, 慎一

• 滝口, 雅文

抄録

type:論文(Article)

HIV-1 escape mutants are well known to be selected by immune pressure via HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies. The ability of the CTLs to suppress HIV-1 replication is assumed to be associated with the selection of escape mutants from the CTLs. Therefore, we first investigated the correlation between the ability of HLA-A*1101-restricted CTLs recognizing immunodominant epitopes in vitro and the selection of escape mutants. The result showed that there was no correlation between the ability of these CTLs to suppress HIV-1 replication in vitro and the appearance of escape mutants. The CTLs that had a strong ability to suppress HIV-1 replication in vitro but failed to select escape mutants expressed a higher level of PD-1 in vivo, whereas those that had a strong ability to suppress HIV-1 replication in vitro and selected escape mutants expressed a low level of PD-1. Ex vivo analysis of these CTLs revealed that the latter CTLs had a significantly stronger ability to recognize the epitope than the former ones. These results suggest that escape mutations are selected by HIV-1-specific CTLs that have a stronger ability to recognize HIV-1 in vivo but not in vitro.

source:0022538X

identifier:http://jvi.asm.org/cgi/content/abstract/84/11/5508

収録刊行物

• Journal of Virology

  Journal of Virology 84 (11), 5508-5519, 2010-06

  American Society for Microbiology

キーワード

• 493.878

詳細情報

• CRID: 1050001337928435456
• NII論文ID: 120002696399
• Web Site: http://hdl.handle.net/2298/17476
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles