Regioselective Synthesis of Trifluoromethyl Group Substituted Pyrazole Derivatives from 1-Aryl-3,4,4,4-tetrafluoro-2-buten-1-ones

• Sano, Keisuke

• Hara, Shoji

抄録

Trifluoromethyl group substituted pyrazole derivatives were prepared from hydrazines and 1-aryl-3,4,4,4-tetrafluoro-2-buten-1-ones obtained by the deoxyfluorination of β-diketones. The reaction proceeded regioselectively and 5-aryl-3-trifluoromethyl-1-phenyl-1H-pyrazole was obtained from phenylhydrazine. On the other hand, when methylhydrazine was used, 3-aryl-5-trifluoromethyl-1-methyl-1H-pyrazole was selectively formed.

収録刊行物

• Heterocycles

  Heterocycles 80 (1), 349-357, 2010-01-01

  Japan Institute of Heterocyclic Chemistry

キーワード

• Trifluoromethylpyrazole
• Tetrafluoro-2-buten-1-one
• Regioselective Reaction
• Celecoxib
• Hydrazine

詳細情報

• CRID: 1050001339007235712
• NII論文ID: 120002834747
• NII書誌ID: AA00663739
• HANDLE: 2115/45015
• NDL書誌ID: 10495675
• ISSN: 03855414
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10495675
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • NDL
  • CiNii Articles