Phagocytic removal of cells that have become unwanted: Implications for animal development and tissue homeostasis

• Nakanishi, Yoshinobu

• Nagaosa, Kazushige

• Shiratsuchi, Akiko

抄録

金沢大学医薬保健研究域薬学系

Cells that have become unwanted need to be promptly, selectively, and safely removed. This is made possible by apoptosis-dependent phagocytosis, in which cells unnecessary, obstructive, or dangerous to organisms are induced to undergo apoptosis so that they are earmarked for phagocytosis. The phagocytic elimination occurs so quickly that cells with hallmarks of apoptosis are barely detectable in vivo. The removal of particular types of cells at appropriate stages of development not only contributes to the disposal of spent cells, the creation of space for morphogenesis, and the exclusion of pathogenic or noxious cells, but seems to actively control tissue renewal, tissue remodeling, tissue function, and pathogenic state. This event thus plays an indispensable role in the maintenance of animal development and tissue homeostasis. © 2011 The Authors. Journal compilation © 2011 Japanese Society of Developmental Biologists.

収録刊行物

• Development Growth and Differentiation

  Development Growth and Differentiation 53 (2), 149-160, 2011-02-01

  Wiley-Blackwell / 日本発生生物学会 = Japanese Society of Developmental Biologists (JSDB)

キーワード

• Cell-cell recognition
• Innate immunity
• Morphogenesis
• Phagocyte
• Tissue homeostasis

詳細情報

• CRID: 1050001335954051328
• NII論文ID: 10027899728
• NII書誌ID: AA00627804
• ISSN: 00121592
• NDL書誌ID: 11015800
• Web Site: http://hdl.handle.net/2297/27315
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11015800
• Web Site: https://search.jamas.or.jp/link/ui/2011158871
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • NDL
  • CiNii Articles