Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.

• 渡部, 則彦

• Kido, Masahiro

• Iwamoto, Satoru

• Nishiura, Hisayo

• Maruoka, Ryutaro

• Tanaka, Junya

• Watanabe, Takeshi

• Tanaka, Yoshimasa

• Okazaki, Taku

• Chiba, Tsutomu

• Watanabe, Norihiko

抄録

To clarify mechanisms involved in the development of autoimmune hepatitis (AIH), we recently developed a mouse model of spontaneous AIH by inducing a concurrent loss of Foxp3(+) regulatory T cells and programmed cell death 1 (PD-1)-mediated signaling. Fatal AIH in these mice was characterized by severe T-cell infiltration and huge production of antinuclear antibodies (Abs). This study aims to identify induction sites, responsible T-cell subsets, and key molecules for induction of AIH.

収録刊行物

• Gastroenterology

  Gastroenterology 140 (4), 1322-1333.e5, 2011-04

キーワード

• Autoimmune Liver Disease
• Pathogenesis
• Follicular Helper T Cells

詳細情報

• CRID: 1050282677278393344
• NII論文ID: 120003001404
• NII書誌ID: AA0065394X
• ISSN: 15280012
• HANDLE: 2433/139747
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles