ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
抄録
The poly(ADP-ribose) polymerases (PARPs) participate in various processes. Here, we report that the PARP-13/ZAP shorter isoform (hereafter called ZAPS), rather than the full length protein, is selectively induced by 3pRNA, and functions as a potent stimulator of retinoic acid-inducible gene-I (RIG-I)-mediated interferon (IFN) responses in human cells. ZAPS associates with RIG-I to promote the oligomerization and ATPase activity of RIG-I, leading to robust activation of IRF3 and NF-κB pathways. Disruption of the PARP-13/ZAP gene, ZC3HAV1, severely abrogated the induction of IFN-α, IFN-β and other cytokines upon viral infection. These results indicate that ZAPS is a key regulator of RIG-I signaling during the innate antiviral immune response, suggesting its possible use as a therapeutic target for viral control.
収録刊行物
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- Nature Immunology
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Nature Immunology 12 (1), 37-44, 2011-01
Nature Publishing Group
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詳細情報
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- CRID
- 1050845763937304192
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- NII論文ID
- 120003118156
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- HANDLE
- 2115/46762
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- ISSN
- 15292908
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles