Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

• Sakurai, Takeshi

• Mieda, Michihiro

抄録

金沢大学医薬保健研究域医学系

Avoiding danger and finding food, which are life-sustaining activities that are regulated by emotion, reward and energy balance, require proper wakefulness. The orexin system controls sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis. Recent findings have brought about the possibility of novel therapies targeting the orexin system for sleep disorders, including insomnia and narcolepsy-cataplexy, as well as other pathological conditions such as obesity and drug addiction . In this review, we will discuss the current understanding of the integrative physiology and clinical perspectives of the orexin system. We will briefly review signaling through orexin A and B receptors and discuss the role of orexins in the pathophysiology of narcolepsy. We will also examine connections between orexin neurons and other brain areas involved in feeding behavior, reward and emotion. Finally, we will consider the therapeutic potential of drugs that target orexin receptors. © 2011 Elsevier Ltd. All rights reserved.

収録刊行物

• Trends in Pharmacological Sciences

  Trends in Pharmacological Sciences 32 (8), 451-462, 2011-08-01

  Elsevier

詳細情報

• CRID: 1050845760883888000
• NII論文ID: 120003141897
• NII書誌ID: AA10625689
• ISSN: 01656147
• Web Site: http://hdl.handle.net/2297/28327
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles