Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model.

• 猪原, 匡史

• Shirakashi, Yoshitomo

• Ihara, Masafumi

• Urushitani, Makoto

• Oono, Miki

• Kawamoto, Yasuhiro

• Yamashita, Hirofumi

• Shimohama, Shun

• Kato, Shinsuke

• Hirano, Asao

• Tomimoto, Hidekazu

• Ito, Hidefumi

• Takahashi, Ryosuke

抄録

Cu/Zn superoxide dismutase (SOD1) is a major component of Lewy body-like hyaline inclusion (LBHI) found in the postmortem tissue of SOD1-linked familial amyotrophic lateral sclerosis (FALS) patients. In our recent studies, 14-3-3 proteins have been found in the ubiquitinated inclusions inside the anterior horn cells of spinal cords with sporadic amyotrophic lateral sclerosis (ALS). To further investigate the role of 14-3-3 proteins in ALS, we performed immunohistochemical analysis of 14-3-3 proteins and compared their distributions with those of SOD1 in FALS patients and SOD1-overexpressing mice.

収録刊行物

• PloS one

  PloS one 6 (5), 2011-05

  Public Library of Science

詳細情報

• CRID: 1050001202065966080
• NII論文ID: 120003163709
• ISSN: 19326203
• HANDLE: 2433/141995
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles