Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.

• 佐々木, 直也

• 石井, 隆道

• Kamimura, Ryo

• Kajiwara, Masatoshi

• Machimoto, Takafumi

• Nakatsuji, Norio

• Suemori, Hirofumi

• Ikai, Iwao

• Yasuchika, Kentaro

• Uemoto, Shinji

抄録

We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance.

収録刊行物

• Cancer letters

  Cancer letters 308 (2), 152-161, 2011-09-28

  Elsevier Ireland Ltd.

キーワード

• Cancer stem cell
• Pancreatic cancer
• Alpha-fetoprotein (AFP)
• ATP-binding cassette
• Sub-family A (ABC1)
• Member 12 (ABCA12)

詳細情報

• CRID: 1050282810697521152
• NII論文ID: 120003290284
• NII書誌ID: AA00598513
• ISSN: 03043835
• HANDLE: 2433/145219
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles