Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation

• Kasahara, Yoshihito

• Miyawaki, Toshio

• Kato, Kimitaka

• Kanegane, Hirokazu

• Yachie, Akihiro

• Yokoi, Toru

• Taniguchi, Noboru

抄録

金沢大学大学院医学系研究科血管病態制御学

The present study was undertaken to elucidate different requirements for CD2-mediated activation of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T112 and anti-T113) mAbs could effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to antiCD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6 - producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule.

収録刊行物

• Journal of Experimental Medicine

  Journal of Experimental Medicine 172 (5), 1419-1424, 1990-01-01

  Rockefeller University Press

詳細情報

• CRID: 1050282810924838784
• NII論文ID: 120003325043
• NII書誌ID: AA00697559
• ISSN: 00221007
• Web Site: http://hdl.handle.net/2297/7447
• Web Site: http://hdl.handle.net/2297/29241
• 本文言語コード: en
• 資料種別: journal article
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