The relationship between stress-induced myocardial ischemia and coronary artery atherosclerosis measured by hybrid SPECT/CT camera

• Matsuo, Shinro

• Nakajima, Kenichi

• Okuda, Koichi

• Kinuya, Seigo

抄録

Objective: The coronary artery calcium (CAC) score and myocardial perfusion imaging can now be detected simultaneously using a hybrid SPECT/CT camera. However, there has been little evaluation on the relationship between stress-induced ischemia and coronary artery calcification in a Japanese population. The aim of this study was to investigate the relationship between these parameters and to elucidate the diagnostic value of the CAC score as an adjunct to myocardial perfusion imaging (MPI) for the assessment of coronary artery disease (CAD) in an intermediate-risk population. Methods: We retrospectively analyzed 105 patients (63% men, mean age 71 years) with CAD or suspected CAD who underwent MPI using SPECT/CT. CAC scanning was performed using a SPECT/CT camera. Results: There was a significant difference in the CAC score between patients with ischemia (n = 42) and those without ischemia (n = 63) (1353 ± 1524 vs. 332 ± 554, p < 0.01). The frequency of ischemic MPI determined by summed difference score tended to be higher in patients with high CAC (CAC = 0; 0.8 ± 1.3 vs. CAC > 1000; 3.0 ± 2.0). Higher age is related roughly with higher CAC score with no statistical significance (r 2 = 0.1) (<60 years old; 200 ± 692, vs. >80 years old; 1258 ± 1546, ns). The location of calcification was not related to the ischemic area. In a population with a predominately intermediate likelihood of CAD, a calcium score of zero has a possibility of excluding inducible ischemia on MPI. In part, ischemic MPI is associated with a high likelihood of subclinical atherosclerosis as detected by CAC. Conclusion: Hybrid SPECT/CT might be useful for diagnostic assessment and coronary artery with known or suspected CAD. © 2011 The Japanese Society of Nuclear Medicine.

収録刊行物

• Annals of Nuclear Medicine

  Annals of Nuclear Medicine 25 (9), 650-656, 2011-11-01

  Springer verlag (Germany) / The Japanese Society of Nuclear Medicine

キーワード

• Coronary calcification
• Diagnostic work-up
• Ischemia
• Normal perfusion
• SPECT/CT

詳細情報

• CRID: 1050845760914003456
• NII論文ID: 10030233081
• NII書誌ID: AA10708017
• ISSN: 09147187
• Web Site: http://hdl.handle.net/2297/29754
• Web Site: https://search.jamas.or.jp/link/ui/2012338797
• 本文言語コード: en
• 資料種別: journal article
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