CD16(+) natural killer cells play a limited role against primary dengue virus infection in tamarins.

• 吉田, 友教

• Omatsu, Tsutomu

• Saito, Akatsuki

• Katakai, Yuko

• Iwasaki, Yuki

• Iijima, Sayuki

• Kurosawa, Terue

• Hamano, Masataka

• Nakamura, Shinichiro

• Takasaki, Tomohiko

• Yasutomi, Yasuhiro

• Kurane, Ichiro

• Akari, Hirofumi

抄録

CD16 is a major molecule expressed on NK cells. To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo, CD16 antibody-treated tamarins were inoculated with a DENV-2 strain. This resulted in the transient depletion of CD16(+) NK cells, whereas no significant effects on the overall levels or kinetics of plasma viral loads and antiviral antibodies were observed in the treated monkeys when compared to control monkeys. It remains elusive whether the CD16(-) NK subpopulation could play an important role in the control of primary DENV infection.

収録刊行物

• Archives of virology

  Archives of virology 157 (2), 363-368, 2012-02

  Springer-Verlag

キーワード

• Dengue virus
• Tamarin
• NK cells
• CD16

詳細情報

• CRID: 1050564285679872256
• NII論文ID: 120003874271
• NII書誌ID: AA00548901
• ISSN: 03048608
• HANDLE: 2433/153290
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles