Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model

• Mizobuchi Satoshi

• Matsuoka Yoshikazu

• Obata Norihiko

• Kaku Ryuji

• Itano Yoshitaro

• Tomotsuka Naoto

• Taniguchi Arata

• Nishie Hiroyuki

• Kanzaki Hirotaka

• Ouchida Mamoru

• Morita Kiyoshi

抄録

Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 66 (3), 285-289, 2012-06

  Okayama University Medical School

キーワード

• beta-blocker
• landiolol
• formalin
• pain behavior
• c-fos

詳細情報

• CRID: 1390009224819463424
• NII論文ID: 120004247100
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/48569
• PubMed: 22729110
• Web Site: https://ousar.lib.okayama-u.ac.jp/48569
• Web Site: https://search.jamas.or.jp/link/ui/2013156724
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • PubMed
  • CiNii Articles