Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes: Assessment using a meal tolerance test under clinical conditions

• Ando, Hitoshi

• Kurita, Seiichiro

• Shimizu, Akiko

• Kato, Ken-ichiro

• Ishikura, Kazuhide

• Taji, Koumei

• Uno, Masafumi

• Takeshita, Yumie

• Misu, Hirofumi

• Fujimura, Akio

• Kaneko, Shuichi

• Takamura, Toshinari

抄録

Few studies have evaluated the pharmacokinetics of rapid-acting insulin analogues in patients with Type 2 diabetes, especially under clinical conditions. The aim of the present study was to assess both the pharmacokinetics and pharmacodynamics of insulin aspart in Type 2 diabetic patients who were being treated with the analogue alone. Meal tolerance tests with and without self-injection of a customary dose of insulin aspart (0.05-0.22 U/kg) were conducted in 20 patients in a randomized cross-over study. The dose of insulin aspart (per bodyweight) was significantly correlated with both the maximum concentration (r 2 = 0.59; P < 0.01) and area under the concentration-time curve for insulin aspart (r 2 = 0.53; P < 0.01). However, the time to maximum concentration (T max), which varied widely from < 60 to ≥ 120 min, was not associated with either dosage (r 2 = 0.02; P = 0.51) or body mass index (r 2 = 0.02; P = 0.57). Injection of insulin aspart exacerbated delayed hyperinsulinaemia after meal loading, mainly in patients with T max ≥ 120 min. With regard to pharmacodynamics, insulin aspart had favourable effects on postprandial hyperglycaemia, hyperglucagonaemia and hyperlipidaemia. The T max for this insulin analogue differed greatly between individuals and delayed hyperinsulinaemia was particularly exacerbated in patients with higher T max values. Identification of the factors contributing to interindividual variation in the absorption lag time is essential for improving the efficacy and safety of insulin aspart. © 2012 The Authors. Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.

収録刊行物

• Clinical and Experimental Pharmacology and Physiology

  Clinical and Experimental Pharmacology and Physiology 39 (6), 528-534, 2012-06-01

  Blackwell

キーワード

• Delayed hyperinsulinaemia
• Glucagon
• Insulin aspart
• Postprandial hyperlipidaemia
• Rapid-acting insulin analogues

詳細情報

• CRID: 1050001335950921472
• NII論文ID: 120004442389
• NII書誌ID: AA00607727
• ISSN: 03051870
• Web Site: http://hdl.handle.net/2297/31973
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles